Dr. Whitaker’s Berberine 1,500mg Supplement

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bottle of Berberine with benefit icons

bilberry plant in dish

glucose in blood stream

senior couple enjoying food together

WHAT is Berberine?

Berberine is a natural plant alkaloid found in goldenseal, barberry, goldthread, and Oregon grape. This well-tolerated extract works at the cellular level to support normal responses, even after eating a meal or sugary treat.

HOW does it work?

In vitro evidence suggests Berberine works by helping to enhance AMPK-activated protein kinase, which controls the synthesis and uptake of glucose transporters that move glucose from your bloodstream into your cells.

WHY should you take it?

Research shows that Berberine supports wellness before and after meals, as well as triglyceride levels, total and LDL cholesterol levels, and blood pressure numbers.*

*Already within the normal range.


500 mg, 3 times daily


quality promise seal

Clinical Validation

One study showed that 1,500 mg of Berberine daily supports normal responses after meals along with 3-month averages. Additional research showed participants with elevated cholesterol and triglyceride levels who took 1,000 mg of berberine daily for three months saw reasonable LDL, triglycerides, and total cholesterol numbers.*

*Already within the normal range.

1,500 mg dosage

The 1,500 mg dosage in Whitaker Nutrition Berberine matches the full researched dosage shown to support wellness with each meal, among other benefits. We recommend 500 mg of Berberine 3X a day with a meal as the best way to deliver maximum results.

Science follows tradition

For centuries, traditional Chinese and Ayurvedic medicines used this miracle herb from Mother Nature—Berberine—to treat all kinds of ailments. Practitioners of Western medicine finally decided the Chinese were onto something. Realizing Berberine’s tremendous potential, researchers began studying its effect with outstanding results. Today, Berberine is the go-to solution for many practitioners.

Premium quality, thorough testing

Whitaker Nutrition Berberine is backed by Healthy Directions’ Triple-Testing Philosophy, which includes rigorous screening of raw materials, finished goods batch testing, and independent third-party lab testing. The result is a stellar 30-year reputation for outstanding quality and safety.

Berberine Bottle of Berberine GlucoGOLD+
Berberine Berberine GlucoGold+
1,500 mg berberine for advanced wellness maintenance
Clinically validated ingredients
Doctor formulated
400 mcg Crominex 3+ Chromium for improving insulin receptor sensitivity
200 mg potent, concentrated cinnamon to support glycemic control
48 mg Banaba Leaf Extract to help maintain wellness levels

Features & Specifications


Pros & Cons


I'm a believer: It lowered my morning fasting, A1C and cholesterol! I was looking for something to help with my diabetes and read about Berberine in a magazine. After researching it online (WebMD, NCBI, and reading user reviews on Amazon), I decided to give it a try. It seemed an all-natural way that might lower my numbers. With diet and exercise I had been in the high 100-120 range, but then I was in the 120s consistently no matter what I did. I was worried my a1c would be above 6.5 at my next doctor visit. I knew if it was, my doctor would want to put me on Metformin and I just don't want to go that route if at all possible. But I was super skeptical about the berberine because I've tried just about everything else natural to lower my numbers and nothing worked. To my surprise, the very first morning after taking the berberine my numbers were in the 90s. Say what? I hadn't seen that in a couple years. Before I got too hopeful though, I reigned in my excitement. I wanted to see what would happen over time. My numbers stayed in the 90s, sometimes even in the 80s. A "high" day was in the 100s (like 107). I used to try and keep my numbers at 110 or under. With the berberine it was possible to shoot for 100 or under. I have now been on it for 3 months. I had to do my 6 month blood work and was curious if this affected my a1C. I had been at 6.5 the previous visit. It dropped to 6.3. In the last month though I wasn't as fastidious about taking it 3x/day. I'm curious if I go back to that if my a1C will drop even more. We'll find out next visit six months from now... I was delighted to see my cholesterol had also improved. From total chol of 200, triglycerides of 100 and LDL of 119 last year to total chol of 189, triglycerides of 87 and LDL of 112 this year. HDL remained consistent both years at 60. I believe the Berberine helped with my cholesterol numbers improving too. Another thing I want to note is tummy issues. When I first started taking the berberine I was also taking reservatol and milk thistle. Not sure what was upsetting my stomach so bad, but after meals it was imperative I be near a bathroom. Which was very inconvenient. I read about the side effects for the other 2 and decided to eliminate them when I learned both can up occurrences of breast cancer, and milk thistle can have a laxative effect. Tummy problems solved. Not sure if it was one of them causing it, a combo of all 3 or what, but that was rough. But on the berberine alone? No problems like that. I love seeing my morning fasting numbers so low though. I feel this stuff is wonderful and am very glad there's a company who provides it. As for the quality...My first couple of bottles were bright yellow capsules. This last bottle was darker yellow (almost a stone ground mustard color) and had a couple broken/smashed capsules. That was a little disconcerting. And my numbers have been back in the 110s and 120s since taking this newest bottle. (But I also haven't been taking 3x/day. Some days I'm lucky just to take it once.) So I'm not sure if this one missed quality control or what, but when I run out I'll order more. Until I feel this isn't working anymore or I have side effects, I'll keep this in my health repertoire.

The best Berberine I have used! This is by far the best Berberine I have ever used. Whenever I take it, I get no harmful side effects and it works well to bring down my blood sugar and even my blood pressure. I stopped taking Metformin because it kept resulting in a vitamin B deficiency. I recently purchased another formula from another doctor that is mixed with Ceylon cinnamon and got a bad reaction. I was denied a return or refund and was not able to get my money back. I am now stuck with the product and I regret straying away from DR. Whitaker's formula. Soon I will be purchasing this item again and will never stray away from it again!

I believe this absolutely works. I am diabetic for over 35 years found out about barbarine because I didn't want to be a metformin anymore I had been taken off it many years ago and recently put back on it and did not want to stay on it so I looked into alternatives... I am absolutely convinced this product works just as good if not better as I have been having low sugar spells which means that some things making my sugar go down and that's the only thing that changed... The only problem that I canceled all my Subscriptions because I had them set up for 3 months and you kept sending everything every montoo bad because I would have liked to have kept up with the good prices maybe you could fix this for me if I sign up again you'll be sending it to me by next month...

Great. This product would be even more ideal if it were 4500 in one pill. Three times a day. Enough for a month.

Ease of use. Got this item today. I have heard great things about it from friends. I have started with two capsules in day and after dinner. Hopefully it should do the trick as has been experienced by some friends.

works well. I am very happy with this product, my cholesterol and triglycerides levels have come down


I wanted it to work. Just does not seem very effective. I have been testing this on my blood sugars for months. Sadly. Despite all the research I read as well, it seems to be the least effective supplement I have used for blood sugar support and not only does not rival metformin (as some articles and sellers on the net suggest), it actually seems to antagonize the benefits of metformin. I was looking for an alternative to metformin because this medicine is known to reduce vitamin 12 absorption and possibly Vit b6 was well. Unknown whether Berberbine does too. BTW. I do not seem to have any obvious side effects from using the supplement, other than the fact that it RAISES my blood sugar reliably by 10-20 points, between meals and for the morning fasting sugar. I have left it out and resumed metformin. Sugars go down below 100. I have added it to metformin. Sugars go up. I have used my other supplements without metformin or Berberine. Sugars go down. I add Berberine back in. Sugars go back up. Finally I continued taking it for a week (with no metformin on board) but kept taking my other supplements. Sugars were not optimal but “okay”. Then I stopped the berberine, but continued the others such as turmeric and blood sugar manager by Nature’s Way. Blood sugars went down again to near 100 or less. Finally then. Daily calories and percent carbohydrates in nearly the same zone each day. I added back this prep of Berberine. And sadly blood sugar went up 15 points. So. Not only am I starting to doubt that it works, I am starting to wonder whether it is in fact counterproductive at least for my blood sugar support. I realize that home glucose monitoring has built in variability because test strips are not held to the kind of high production standards that are truly needed. Nonetheless. Across weeks and repeated testing it seems to actually be consistently raising my blood sugar regardless whether I am using metformin or not. In contrast. Metformin plus the turmeric, Blood Sugar Manager or the older supplements I liked but are no longer available (Level Right and one I no longer remember the name of) all seemed to work together in at least an additive fashion to get bloood sugars to 80s or 90s but never too low. I like the sound of Berberine’s reported benefits. Sadly I cannot say that it has been working well enough for me to continue. So I just cancelled my subscription to it. By the way. I also exercise daily at least 20 min on Schwinn Airdyne Pro. Sometimes more. Metformin and the other supplements have worked in predictable trustworthy fashion along side exercise. However. Even exercise has not seemed to boost this preparation of Berberine. I suppose I could try another source of it before completely giving up on this AMPK activator.

Don’t think it works as advertised. Not good

I won't use this with metformin. This is from a reputable company that does well in testing for content but it doesn't state the source of the type of plant the berberine comes from. I recently read a test report claiming that goldenseal reduces the effectiveness of metformin. If this is not a problem for you then I can recommend this with a 5 star rating.

Not as labeled. These are 500 mg tablets not 1500mg,as the label states. Very misleading. Thought i was getting a 90 day supply.

Shortchanged on Capsules. I have absolutely no idea whatsoever if this product is actually working for me, until my next Blood Test in June 2023. I am tolerating it well, with no GI Side Effects. The last two bottles of Dr. Whitaker's Berberine 1,500 Mg. contained only 89 Capsules instead of 90. The Lot Number is XOOOBY1J6F, ordered on Amazon. At first, I thought it might be an Honest Mistake. However, when it happened a Second Time, my thoughts were that this is a Deliberate Action on the part of the Manufacturer. When I pay for 90 Capsules, my expectation is to receive 90 Capsules !!! Therefore, I cannot give this product a higher rating at this point in time. My Rating might be revised, contingent on achieving good Blood Sugar results from the Lab in June 2023. Allen J. Frankel Sunday April 02, 2023

Not for someone with normal to boarder line blood sugar. This product isn’t for someone with normal to even boarder line blood sugar levels. This product can cause your levels to bottom out causing extreme sweating, headache, shaking, and all around uneasy feeling. Only take this after speaking to your healthcare provider. Additionally, this Item doesn’t qualify for return!!!!!!

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Existing Customer Reviews

The last thing to check is customer reviews. No matter how many the features are, no matter how powerful the specs are, you must verify that by lookig into existing customer reviews generally listed right after the features and specs, or before the bottom of the page. See what they say about the products, how they feel and probably an update after one or two months' use. Finally, make a decision to buy or not to.


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